Catheter lock solution taurolidine, heparin and citrate

Why Neutrolin ?

Neutrolin^®

First-in-class, non-antibiotic solution that prevents infections and thrombosis associated with central venous catheters.

• Neutrolin^®consists of taurolidine 1.35 %, heparin 1,000 units/mL and citrate 3.5 %: 
  
  
  • Taurolidine 1.35 % is a synthetic broad-spectrum anti-bacterial and anti-fungal compound that is metabolized to the amino acid taurine in humans, which limits its  toxicity for clinical use
  • Heparin 1,000 units/mL is added to Neutrolin as a well-established anticoagulant
  • Citrate 3.5 % is added as a buffer to ensure that taurolidine remains in solution at ~ pH 6
• Neutrolin^®is an antimicrobial and anticoagulant catheter lock solution for hemodialysis patients
• Neutrolin^®provides protection against catheter-related blood stream infections (CRBSI) and helps  to maintain catheter patency

Attributes of Neutrolin® which improve lock effectiveness²:

• Broad-spectrum antimicrobial effect against bacteria and fungi
• Safe and compatible with tissue and blood
• No evidence of bacterial resistance in human
• No systemic pharmacological effect
• Inactivation of endotoxin
• Reduces adherence of bacteria and blood to surfaces
• Protects against infection¹
• Prevents thrombosis¹

Active ingredient – taurolidine

• Taurolidine is a unique nontoxic substance that eliminates binding of bacteria and some fungi  to the surface
• Taurolidine is NOT an antibiotic and it has never demonstrated bacterial resistance
• Taurolidine is a broad-spectrum antimicrobial active substance against virulent bacteria and fungi,  responsible for most HD infections
• Taurolidine has proven effective in preventing catheter colonization at the planktonic level  and eradication of a developed biofilm in several types of in vitro tests